Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma

To successfully target Notch receptors as part of a multidrug anticancer strategy, it will be essential to fully characterize the factors that are modulated by Notch signaling. We recently reported that Notch3 silencing in HCC results in p53 up-regulation in vitro and, therefore, we focused on the m...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Giovannini, Catia, Minguzzi, Manuela, Baglioni, Michele, Fornari, Francesca, Giannone, Ferdinando, Ravaioli, Matteo, Cescon, Matteo, Chieco, Pasquale, Bolondi, Luigi, Gramantieri, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279397/
https://ncbi.nlm.nih.gov/pubmed/25431954
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