Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes

BACKGROUND: Intratumoral heterogeneity may help drive resistance to targeted therapies in cancer. In breast cancer, the presence of nodal metastases is a key indicator of poorer overall survival. The aim of this study was to identify somatic genetic alterations in early dissemination of breast cance...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Blighe, Kevin, Kenny, Laura, Patel, Naina, Guttery, David S., Page, Karen, Gronau, Julian H., Golshani, Cyrus, Stebbing, Justin, Coombes, R. Charles, Shaw, Jacqueline A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278903/
https://ncbi.nlm.nih.gov/pubmed/25546409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115346
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