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Astrocytes Protect Neurons from Aβ(1-42) Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1
One of the earliest neuropathological events in Alzheimer's disease is accumulation of astrocytes at sites of Aβ(1-42) depositions. Our results indicate that Aβ(1-42) toxic peptide increases lipid peroxidation, apoptosis and cell death in neurons but not in astrocytes in primary culture. Aβ(1-4...
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| Izdano u: | Int J Med Sci |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Ivyspring International Publisher
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4278875/ https://ncbi.nlm.nih.gov/pubmed/25552918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.10035 |
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