Astrocytes Protect Neurons from Aβ(1-42) Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1

One of the earliest neuropathological events in Alzheimer's disease is accumulation of astrocytes at sites of Aβ(1-42) depositions. Our results indicate that Aβ(1-42) toxic peptide increases lipid peroxidation, apoptosis and cell death in neurons but not in astrocytes in primary culture. Aβ(1-4...

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Publicado en:Int J Med Sci
Autores principales: Aguirre-Rueda, Diana, Guerra-Ojeda, Sol, Aldasoro, Martin, Iradi, Antonio, Obrador, Elena, Ortega, Angel, Mauricio, M. Dolores, Vila, Jose Mª, Valles, Soraya L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278875/
https://ncbi.nlm.nih.gov/pubmed/25552918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.10035
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