Astrocytes Protect Neurons from Aβ(1-42) Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1

One of the earliest neuropathological events in Alzheimer's disease is accumulation of astrocytes at sites of Aβ(1-42) depositions. Our results indicate that Aβ(1-42) toxic peptide increases lipid peroxidation, apoptosis and cell death in neurons but not in astrocytes in primary culture. Aβ(1-4...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Int J Med Sci
Hlavní autoři: Aguirre-Rueda, Diana, Guerra-Ojeda, Sol, Aldasoro, Martin, Iradi, Antonio, Obrador, Elena, Ortega, Angel, Mauricio, M. Dolores, Vila, Jose Mª, Valles, Soraya L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278875/
https://ncbi.nlm.nih.gov/pubmed/25552918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.10035
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky