Disruption of human papillomavirus 16 E6 gene by clustered regularly interspaced short palindromic repeat/Cas system in human cervical cancer cells

High-risk human papillomavirus (HPV), especially HPV16, is considered a main causative agent of cervical cancer. Upon HPV infection, the viral oncoprotein E6 disrupts the host tumor-suppressor protein p53, thus promoting malignant transformation of normal cervical cells. Here, we used the newly deve...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Yu, Lan, Wang, Xiaoli, Zhu, Da, Ding, Wencheng, Wang, Liming, Zhang, Changlin, Jiang, Xiaohui, Shen, Hui, Liao, Shujie, Ma, Ding, Hu, Zheng, Wang, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278796/
https://ncbi.nlm.nih.gov/pubmed/25565864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S64092
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