Transient Receptor Potential Vanilloid 1 Gene Deficiency Ameliorates Hepatic Injury in a Mouse Model of Chronic Binge Alcohol-Induced Alcoholic Liver Disease

Experimental alcohol-induced liver injury is exacerbated by a high polyunsaturated fat diet rich in linoleic acid. We postulated that bioactive oxidized linoleic acid metabolites (OXLAMs) play a critical role in the development/progression of alcohol-mediated hepatic inflammation and injury. OXLAMs...

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Publicat a:Am J Pathol
Autors principals: Liu, Huilin, Beier, Juliane I., Arteel, Gavin E., Ramsden, Christopher E., Feldstein, Ariel E., McClain, Craig J., Kirpich, Irina A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2015
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278357/
https://ncbi.nlm.nih.gov/pubmed/25447051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.09.007
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