Dual EGFR inhibition in combination with anti-VEGF treatment in colorectal cancer

Preclinical studies demonstrate that epidermal growth factor receptor (EGFR) signals through both kinase-dependent and independent pathways and that combining a small-molecule EGFR inhibitor, EGFR antibody, and/or anti-angiogenic agent is synergistic. We conducted a dose-escalation, phase I study co...

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Veröffentlicht in:Oncoscience
Hauptverfasser: Falchook, Gerald S., Naing, Aung, Wheler, Jennifer J., Tsimberidou, Apostolia M., Zinner, Ralph, Hong, David S., Fu, Siqing, Piha-Paul, Sarina A., Janku, Filip, Hess, Kenneth R., Bastida, Christel, Kurzrock, Razelle
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278330/
https://ncbi.nlm.nih.gov/pubmed/25594061
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