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Cytotoxicity of RNase Sa to the acute myeloid leukemia Kasumi-1 cells depends on the net charge
The majority of known cytotoxic RNases are basic proteins which destroy intracellular RNA. Cationization of RNases is considered to be an effective strategy for strengthening their antitumor properties. We constructed a set of RNase Sa variants consisting of charge reversal mutants, charge neutraliz...
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| Publicado no: | Oncoscience |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4278273/ https://ncbi.nlm.nih.gov/pubmed/25594000 |
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