Identification of a class of human cancer germline genes with transcriptional silencing refractory to the hypomethylating drug 5-aza-2′-deoxycytidine.

Bona fide germline genes have expression restricted to the germ cells of the gonads. Testis-specific germline development-associated genes can become activated in cancer cells and can potentially drive the oncogenic process and serve as therapeutic/biomarker targets; such germline genes are referred...

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Détails bibliographiques
Publié dans:Oncoscience
Auteurs principaux: Almatrafi, Ahmed, Feichtinger, Julia, Vernon, Ellen G., Escobar, Natalia Gomez, Wakeman, Jane A., Larcombe, Lee D., McFarlane, Ramsay J.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2014
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278271/
https://ncbi.nlm.nih.gov/pubmed/25594001
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