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A Price To Pay for Relaxed Substrate Specificity: A Comparative Kinetic Analysis of the Class II Lanthipeptide Synthetases ProcM and HalM2

[Image: see text] Lanthipeptides are a class of ribosomally synthesized and posttranslationally modified peptide natural products (RiPPs) that typically harbor multiple intramolecular thioether linkages. For class II lanthipeptides, these cross-links are installed in a multistep reaction pathway by...

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Publicado en:J Am Chem Soc
Main Authors: Thibodeaux, Christopher J., Ha, Taekjip, van der Donk, Wilfred A.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2014
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277782/
https://ncbi.nlm.nih.gov/pubmed/25409537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5089452
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