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Bacteriorhodopsin Folds through a Poorly Organized Transition State

[Image: see text] The folding mechanisms of helical membrane proteins remain largely uncharted. Here we characterize the kinetics of bacteriorhodopsin folding and employ φ-value analysis to explore the folding transition state. First, we developed and confirmed a kinetic model that allowed us to ass...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Schlebach, Jonathan P., Woodall, Nicholas B., Bowie, James U., Park, Chiwook
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277764/
https://ncbi.nlm.nih.gov/pubmed/25369295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja508359n
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