Binge Alcohol Consumption Aggravates Oxidative Stress and Promotes Pathogenesis of NASH from Obesity-Induced Simple Steatosis

The pathogenesis of nonalcoholic steatohepatitis (NASH) is a two-stage process in which steatosis is the “first hit” and an unknown “second hit.” We hypothesized that “a binge” could be a “second hit” to develop NASH from obesity-induced simple steatosis. Thirty-week-old male Otsuka Long-Evans Tokus...

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Bibliografske podrobnosti
izdano v:Mol Med
Main Authors: Minato, Takahiro, Tsutsumi, Mikihiro, Tsuchishima, Mutsumi, Hayashi, Nobuhiko, Saito, Takashi, Matsue, Yasuhiro, Toshikuni, Nobuyuki, Arisawa, Tomiyasu, George, Joseph
Format: Artigo
Jezik:Inglês
Izdano: ScholarOne 2014
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277551/
https://ncbi.nlm.nih.gov/pubmed/25180626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2014.00048
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