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AID induces intraclonal diversity and genomic damage in CD86(+) chronic lymphocytic leukemia cells
The activation-induced cytidine deaminase (AID) mediates somatic hypermutation and class switch recombination of the Ig genes by directly deaminating cytosines to uracils. As AID causes a substantial amount of off-target mutations, its activity has been associated with lymphomagenesis and clonal evo...
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| Pubblicato in: | Eur J Immunol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BlackWell Publishing Ltd
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4276288/ https://ncbi.nlm.nih.gov/pubmed/25179679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201344421 |
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