Inhibition of 15-lipoxygenase (15-LOX) reverses hypoxia-induced down-regulation of potassium channels Kv1.5 and Kv2.1Inhibition of 15-lipoxygenase (15-LOX) reverses hypoxia-induced down-regulation of potassium channels Kv1.5 and Kv2.1

The inhibition of voltage-gated potassium channels (Kv) plays an important role in the cerebral hypoxia-induced cell death. The activity of Kv can be inhibited by 15-hydroxyeicosatetrienoic acid (15-HETE). Therefore, as the key enzyme which catalyzed the formation of 15-HETE, 15-LOX may be involved...

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Bibliographic Details
Published in:Int J Clin Exp Med
Main Authors: Liu, Wenjuan, Wang, Di, Song, Kaibin, Chen, Li, Zhu, Yanmei, Liu, Peifang, Zhu, Yulan
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276183/
https://ncbi.nlm.nih.gov/pubmed/25550925
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