Re-Thinking Composite Endpoints in Clinical Trials: Insights from Patients and Trialists

BACKGROUND: Many clinical trials use composite endpoints to reduce sample size, but the relative importance of each individual endpoint within the composite may differ between patients and researchers. METHODS AND RESULTS: We asked 785 cardiovascular patients and 164 clinical trial authors to assign...

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Udgivet i:Circulation
Main Authors: Stolker, Joshua M., Spertus, John A., Cohen, David J., Jones, Philip G., Jain, Kaushik K., Bamberger, Emily, Lonergan, Brady B., Chan, Paul S.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275445/
https://ncbi.nlm.nih.gov/pubmed/25200210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.006588
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