Evolution of RNA-Protein Interactions: Non-Specific Binding Led to RNA Splicing Activity of Fungal Mitochondrial Tyrosyl-tRNA Synthetases

The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (mtTyrRS; CYT-18 protein) evolved a new function as a group I intron splicing factor by acquiring the ability to bind group I intron RNAs and stabilize their catalytically active RNA structure. Previous studies showed: (i) CYT-18 binds grou...

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Bibliografiska uppgifter
I publikationen:PLoS Biol
Huvudupphovsmän: Lamech, Lilian T., Mallam, Anna L., Lambowitz, Alan M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275181/
https://ncbi.nlm.nih.gov/pubmed/25536042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002028
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