Anti-thymocyte globulin facilitates alloreactive T-cell apoptosis via caspase-3: potential implications for monitoring rejection-free outcomes

BACKGROUND: Alloreactive T-cell apoptosis may explain reduced immunosuppression requirements with pro-apoptotic immunosuppression and among rejection-free recipients. This possibility remains unproven. METHODS: Apoptotic (caspase-3+, cathepsin-B+) and inflammatory (CD154+) T-cell subsets were evalua...

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Publicado en:Transplantation
Main Authors: Ashokkumar, Chethan, Sun, Qing, Ningappa, Mylarappa, Higgs, Brandon W., Mazariegos, George, Zeevi, Adriana, Sindhi, Rakesh
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274752/
https://ncbi.nlm.nih.gov/pubmed/25531894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000000289
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