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Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion

The cholesterol reducing drugs, statins, exhibit anti-tumor effects against cancer stem cells and various cancer cell lines, exert potent additivity or synergy with existing chemotherapeutics in animal models of cancer and may reduce cancer incidence and cancer related mortality in humans. However,...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Warita, Katsuhiko, Warita, Tomoko, Beckwitt, Colin H., Schurdak, Mark E., Vazquez, Alexei, Wells, Alan, Oltvai, Zoltán N.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274516/
https://ncbi.nlm.nih.gov/pubmed/25534349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07593
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