Neural-Specific Deletion of Htra2 Causes Cerebellar Neurodegeneration and Defective Processing of Mitochondrial OPA1

HTRA2, a serine protease in the intermembrane space, has important functions in mitochondrial stress signaling while its abnormal activity may contribute to the development of Parkinson’s disease. Mice with a missense or null mutation of Htra2 fail to thrive, suffer striatal neuronal loss, and a par...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Patterson, Victoria L., Zullo, Alfred J., Koenig, Claire, Stoessel, Sean, Jo, Hakryul, Liu, Xinran, Han, Jinah, Choi, Murim, DeWan, Andrew T., Thomas, Jean-Leon, Kuan, Chia-Yi, Hoh, Josephine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4274161/
https://ncbi.nlm.nih.gov/pubmed/25531304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115789
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