Th1/Th17 Plasticity Is a Marker of Advanced β Cell Autoimmunity and Impaired Glucose Tolerance in Humans

Upregulation of IL-17 immunity and detrimental effects of IL-17 on human islets have been implicated in human type 1 diabetes. In animal models, the plasticity of Th1/Th17 cells contributes to the development of autoimmune diabetes. In this study, we demonstrate that the upregulation of the IL-17 pa...

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Bibliografische gegevens
Gepubliceerd in:J Immunol
Hoofdauteurs: Reinert-Hartwall, Linnea, Honkanen, Jarno, Salo, Harri M., Nieminen, Janne K., Luopajärvi, Kristiina, Härkönen, Taina, Veijola, Riitta, Simell, Olli, Ilonen, Jorma, Peet, Aleksandr, Tillmann, Vallo, Knip, Mikael, Vaarala, Outi, Koski, Katriina, Koski, Matti, Ryhänen, Samppa, Hämäläinen, Anu-Maaria, Ormisson, Anne, Ulich, Valentina, Kuzmicheva, Elena, Mokurov, Sergei, Markova, Svetlana, Pylova, Svetlana, Isakova, Marina, Shakurova, Elena, Petrov, Vladimir, Dorshakova, Natalya V., Karapetyan, Tatyana, Varlamova, Tatyana, Kiviniemi, Minna, Alnek, Kristi, Janson, Helis, Uibo, Raivo, Salum, Tiit, von Mutius, Erika, Weber, Juliane, Ahlfors, Helena, Kallionpää, Henna, Laajala, Essi, Lahesmaa, Riitta, Lähdesmäki, Harri, Moulder, Robert, Nieminen, Janne, Ruohtula, Terhi, Honkanen, Hanna, Hyöty, Heikki, Kondrashova, Anita, Oikarinen, Sami, Harmsen, Hermie J. M., De Goffau, Marcus C., Welling, Gjalt, Alahuhta, Kirsi, Virtanen, Suvi M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AAI 2015
Onderwerpen:
Autoimmunity
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273995/
https://ncbi.nlm.nih.gov/pubmed/25480564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401653
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