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Super-Resolution Fluorescence of Huntingtin Reveals Growth of Globular Species into Short Fibers and Coexistence of Distinct Aggregates

[Image: see text] Polyglutamine-expanded huntingtin, the protein encoded by HTT mutations associated with Huntington’s disease, forms aggregate species in vitro and in vivo. Elucidation of the mechanism of growth of fibrillar aggregates from soluble monomeric protein is critical to understanding the...

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Dettagli Bibliografici
Pubblicato in:ACS Chem Biol
Autori principali: Duim, Whitney C., Jiang, Yan, Shen, Koning, Frydman, Judith, Moerner, W. E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273975/
https://ncbi.nlm.nih.gov/pubmed/25330023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500335w
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