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Purine Metabolism in Normal and Thioguanine-Resistant Neuroblastoma

Purine metabolism has been examined in a clonal line of mouse neuroblastoma cells resistant to the cytotoxic effects of 6-thioguanine. Comparative studies in the resistant and parental lines indicate that the former cells have less than 1% of normal hypoxanthine phosphoribosyltransferase (EC 2.4.2.8...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Wood, Alexander W., Becker, Michael A., Minna, John D., Seegmiller, J. Edwin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1973
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC427349/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4521214/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.12.3880
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