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Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown
The mammalian target of rapamycin (mTOR) kinase is a master regulator of cellular, developmental, and metabolic processes. Deregulation of mTOR signaling is implicated in numerous human diseases including cancer and diabetes. mTOR functions as part of either of the two multisubunit complexes, mTORC1...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4273350/ https://ncbi.nlm.nih.gov/pubmed/25453101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419425111 |
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