Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.

Two ionizing radiation-sensitive (IRs) and DNA double-strand break (DSB) mutants, sxi-3 and sxi-2, were shown to be severely deficient in a DNA end binding activity, similar to a previously described activity of the Ku autoantigen, correlating with the xrs (XRCC5) mutations. Cell fusions with xrs-6,...

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Main Authors: Boubnov, N V, Hall, K T, Wills, Z, Lee, S E, He, D M, Benjamin, D M, Pulaski, C R, Band, H, Reeves, W, Hendrickson, E A
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC42726/
https://ncbi.nlm.nih.gov/pubmed/7846073
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