Interleukin-17 receptor A signaling in transformed enterocytes promotes early colorectal tumorigenesis

Interleukin-17A (IL-17A) is a proinflammatory cytokine linked to rapid malignant progression of colorectal cancer (CRC) and therapy resistance. IL-17A exerts its pro-tumorigenic activity through its type A receptor (IL-17RA). However, how IL-17RA engagement promotes colonic tumorigenesis is unknown,...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Wang, Kepeng, Kim, Min Kyoung, Di Caro, Giuseppe, Wong, Jerry, Shalapour, Shabnam, Wan, Jun, Zhang, Wei, Zhong, Zhenyu, Sanchez-Lopez, Elsa, Wu, Li-Wha, Taniguchi, Koji, Feng, Ying, Fearon, Eric, Grivennikov, Sergei I., Karin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272447/
https://ncbi.nlm.nih.gov/pubmed/25526314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.11.009
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