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The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism

Vibrio cholerae is lethal to the model host Drosophila melanogaster through mechanisms not solely attributable to cholera toxin. To examine additional virulence determinants, we performed a genetic screen in V. cholerae-infected Drosophila and identified the two-component system CrbRS. CrbRS control...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Hang, Saiyu, Purdy, Alexandra E., Robins, William P, Wang, Zhipeng, Mandal, Manabendra, Chang, Sarah, Mekalanos, John J, Watnick, Paula I
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4272434/
https://ncbi.nlm.nih.gov/pubmed/25525791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.10.006
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