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Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A).

We have tested the extent of immune self-tolerance to the ubiquitously expressed nuclear/cytoplasmic autoantigens La (SS-B) and Ro (SS-A) in healthy, nonautoimmune mice. Immunization of mice with recombinant mouse La resulted in a specific, isotype-switched autoantibody response, which was initially...

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Autors principals: Topfer, F, Gordon, T, McCluskey, J
Format: Artigo
Idioma:Inglês
Publicat: 1995
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC42723/
https://ncbi.nlm.nih.gov/pubmed/7846070
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