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Toward More Accurate Ancestral Protein Genotype–Phenotype Reconstructions with the Use of Species Tree-Aware Gene Trees

The resurrection of ancestral proteins provides direct insight into how natural selection has shaped proteins found in nature. By tracing substitutions along a gene phylogeny, ancestral proteins can be reconstructed in silico and subsequently synthesized in vitro. This elegant strategy reveals the c...

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Библиографические подробности
Опубликовано в: :Mol Biol Evol
Главные авторы: Groussin, Mathieu, Hobbs, Joanne K., Szöllősi, Gergely J., Gribaldo, Simonetta, Arcus, Vickery L., Gouy, Manolo
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271536/
https://ncbi.nlm.nih.gov/pubmed/25371435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msu305
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