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Constitutive Activation of MEK1 Promotes Treg Cell Instability in Vivo

The instability of regulatory T (Treg) cells is involved in the pathogenesis of autoimmune diseases and also highlights safety concerns with regard to clinical Treg cell therapy. Cell-intrinsic molecular events linked to this Treg cell instability in vivo cells, which leads to safety concerns regard...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Guo, Jitao, Zhang, Jianhua, Zhang, Xuejie, Zhang, Zhongmei, Wei, Xundong, Zhou, Xuyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271203/
https://ncbi.nlm.nih.gov/pubmed/25361764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589192
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