Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation

High mobility group box 1 (HMGB1) is a chromatin-binding protein that maintains DNA structure. On cellular activation or injury, HMGB1 is released from activated immune cells or necrotic tissues and acts as a damage-associated molecular pattern to activate Toll-like receptor 4 (TLR4). Little is know...

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Gepubliceerd in:Blood
Hoofdauteurs: Xu, Hao, Wandersee, Nancy J., Guo, YiHe, Jones, Deron W., Holzhauer, Sandra L., Hanson, Madelyn S., Machogu, Evans, Brousseau, David C., Hogg, Neil, Densmore, John C., Kaul, Sushma, Hillery, Cheryl A., Pritchard, Kirkwood A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2014
Onderwerpen:
Red Cells, Iron, and Erythropoiesis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271182/
https://ncbi.nlm.nih.gov/pubmed/25339362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-560813
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