Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation

High mobility group box 1 (HMGB1) is a chromatin-binding protein that maintains DNA structure. On cellular activation or injury, HMGB1 is released from activated immune cells or necrotic tissues and acts as a damage-associated molecular pattern to activate Toll-like receptor 4 (TLR4). Little is know...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Xu, Hao, Wandersee, Nancy J., Guo, YiHe, Jones, Deron W., Holzhauer, Sandra L., Hanson, Madelyn S., Machogu, Evans, Brousseau, David C., Hogg, Neil, Densmore, John C., Kaul, Sushma, Hillery, Cheryl A., Pritchard, Kirkwood A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2014
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271182/
https://ncbi.nlm.nih.gov/pubmed/25339362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-560813
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