HTLV-1 Tax-Mediated Inhibition of FOXO3a Activity Is Critical for the Persistence of Terminally Differentiated CD4(+) T Cells

The mechanisms involved in the persistence of activated CD4(+) T lymphocytes following primary human T leukemia/lymphoma virus type 1 (HTLV-1) infection remain unclear. Here, we demonstrate that the HTLV-1 Tax oncoprotein modulates phosphorylation and transcriptional activity of the FOXO3a transcrip...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Olagnier, David, Sze, Alexandre, Bel Hadj, Samar, Chiang, Cindy, Steel, Courtney, Han, Xiaoying, Routy, Jean-Pierre, Lin, Rongtuan, Hiscott, John, van Grevenynghe, Julien
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270795/
https://ncbi.nlm.nih.gov/pubmed/25521510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004575
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