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Notch Signaling Mediates the Age-Associated Decrease in Adhesion of Germline Stem Cells to the Niche

Stem cells have an innate ability to occupy their stem cell niche, which in turn, is optimized to house stem cells. Organ aging is associated with reduced stem cell occupancy in the niche, but the mechanisms involved are poorly understood. Here, we report that Notch signaling is increased with age i...

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Xehetasun bibliografikoak
Argitaratua izan da:PLoS Genet
Egile Nagusiak: Tseng, Chen-Yuan, Kao, Shih-Han, Wan, Chih-Ling, Cho, Yueh, Tung, Shu-Yun, Hsu, Hwei-Jan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270478/
https://ncbi.nlm.nih.gov/pubmed/25521289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004888
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