Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation

BACKGROUND: Down-modulation of the CD4 receptor is one of the hallmarks of HIV-1 infection and it is believed to confer a selective replicative advantage to the virus in vivo. This process is mainly mediated by three viral proteins: Env, Vpu and Nef. To date, the mechanisms that lead to CD4 depletio...

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Veröffentlicht in:Retrovirology
Hauptverfasser: Landi, Alessia, Vermeire, Jolien, Iannucci, Veronica, Vanderstraeten, Hanne, Naessens, Evelien, Bentahir, Mostafa, Verhasselt, Bruno
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269872/
https://ncbi.nlm.nih.gov/pubmed/25496667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0118-4
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