Methotrexate-mediated inhibition of nuclear factor κB activation by distinct pathways in T cells and fibroblast-like synoviocytes

Objectives. Nuclear factor κB (NF-κB) is a critical activator of inflammatory processes and MTX is one of the most commonly prescribed DMARDs for treatment of RA. We sought to determine whether MTX inhibited NF-κB activity in RA and in lymphocytes and fibroblast-like synoviocytes (FLSs) and to defin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Rheumatology (Oxford)
Egile Nagusiak: Spurlock, Charles F., Gass, Henry M., Bryant, Carson J., Wells, Benjamin C., Olsen, Nancy J., Aune, Thomas M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2015
Gaiak:
Basic and Translational Science
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269792/
https://ncbi.nlm.nih.gov/pubmed/25118313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/keu279
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