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Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters
Urea transporters (UT) play an important role in the urine concentration mechanism by mediating intrarenal urea recycling, suggesting that UT inhibitors could have therapeutic use as a novel class of diuretic. Recently, we found a thienoquinolin UT inhibitor, PU-14, that exhibited diuretic activity....
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| Pubblicato in: | Am J Physiol Renal Physiol |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4269692/ https://ncbi.nlm.nih.gov/pubmed/25298523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00421.2014 |
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