Radiofrequency Ablation–Induced Upregulation of Hypoxia-Inducible Factor-1α Can Be Suppressed with Adjuvant Bortezomib or Liposomal Chemotherapy

PURPOSE: To characterize upregulation of hypoxia-inducible factor (HIF)-1α after radiofrequency (RF) ablation and the influence of an adjuvant HIF-1α inhibitor (bortezomib) and nanodrugs on modulating RF ablation–upregulated hypoxic pathways. MATERIALS AND METHODS: Fisher 344 rats (n = 68) were used...

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Vydáno v:J Vasc Interv Radiol
Hlavní autoři: Moussa, Marwan, Goldberg, S. Nahum, Kumar, Gaurav, Sawant, Rupa R., Levchenko, Tatyana, Torchilin, Vladimir, Ahmed, Muneeb
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269608/
https://ncbi.nlm.nih.gov/pubmed/25439675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvir.2014.08.025
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