An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice

Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models of Alzheimer’s disease (AD). We show that in an aged transgenic AD mouse model (APP/PS1 plaque-bearing mice), the antidepressant citalopram, a selective serotonin reuptake inhibitor (SSRI), decreased Aβ in brai...

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Publié dans:Sci Transl Med
Auteurs principaux: Sheline, Yvette I., West, Tim, Yarasheski, Kevin, Swarm, Robert, Jasielec, Mateusz S., Fisher, Jonathan R., Ficker, Whitney D., Yan, Ping, Xiong, Chengjie, Frederiksen, Christine, Grzelak, Monica V., Chott, Robert, Bateman, Randall J., Morris, John C., Mintun, Mark A., Lee, Jin-Moo, Cirrito, John R.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269372/
https://ncbi.nlm.nih.gov/pubmed/24828079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008169
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