Partial Restoration of Normal Functional Properties in Carboxypeptidase A-Digested Hemoglobin

In the absence of organic phosphates human hemoglobin A digested with carboxypeptidase A (des His, Tyr β) has high ligand affinity, a greatly reduced Bohr effect, and no heme-heme interaction. Under these conditions, it shows the simple, homogeneous ligand-binding kinetics characteristic of noncoope...

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Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Bonaventura, Joseph, Bonaventura, Celia, Giardina, Bruno, Antonini, Eraldo, Brunori, Maurizio, Wyman, Jeffries
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1972
Soggetti:	Biological Sciences: Biochemistry
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC426894/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4506087/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.69.8.2174
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