Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice

Mechanisms underlying central neuropathic pain are poorly understood. Although glial dysfunction has been functionally linked with neuropathic pain, very little is known about modulation of pain by oligodendrocytes. Here we report that genetic ablation of oligodendrocytes rapidly triggers a pattern...

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Publicat a:Nat Commun
Autors principals: Gritsch, Simon, Lu, Jianning, Thilemann, Sebastian, Wörtge, Simone, Möbius, Wiebke, Bruttger, Julia, Karram, Khalad, Ruhwedel, Torben, Blanfeld, Michaela, Vardeh, Daniel, Waisman, Ari, Nave, Klaus-Armin, Kuner, Rohini
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268702/
https://ncbi.nlm.nih.gov/pubmed/25434649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6472
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