Intra-Arterial Delivery of AAV Vectors to the Mouse Brain After Mannitol Mediated Blood Brain Barrier Disruption

The delivery of therapeutics to neural tissue is greatly hindered by the blood brain barrier (BBB). Direct local delivery via diffusive release from degradable implants or direct intra-cerebral injection can bypass the BBB and obtain high concentrations of the therapeutic in the targeted tissue, how...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Foley, Conor P., Rubin, David G., Santillan, Alejandro, Sondhi, Dolan, Dyke, Jonathan P., Crystal, Ronald G., Gobin, Y. Pierre, Ballon, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268109/
https://ncbi.nlm.nih.gov/pubmed/25270115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.09.018
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