Uric Acid Promotes Apoptosis in Human Proximal Tubule Cells by Oxidative Stress and the Activation of NADPH Oxidase NOX 4

Mild hyperuricemia has been linked to the development and progression of tubulointerstitial renal damage. However the mechanisms by which uric acid may cause these effects are poorly explored. We investigated the effect of uric acid on apoptosis and the underlying mechanisms in a human proximal tubu...

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Publicat a:PLoS One
Autors principals: Verzola, Daniela, Ratto, Elena, Villaggio, Barbara, Parodi, Emanuele Luigi, Pontremoli, Roberto, Garibotto, Giacomo, Viazzi, Francesca
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267812/
https://ncbi.nlm.nih.gov/pubmed/25514209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115210
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