A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration and considered as an endoplasmic reticulum (ER) disease. Despite the underlying importance of ER dysfunction in Wolfram syndrome and the identification of two causative genes, Wolfram syndrome 1 (WFS1) and Wolfram...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Lu, Simin, Kanekura, Kohsuke, Hara, Takashi, Mahadevan, Jana, Spears, Larry D., Oslowski, Christine M., Martinez, Rita, Yamazaki-Inoue, Mayu, Toyoda, Masashi, Neilson, Amber, Blanner, Patrick, Brown, Cris M., Semenkovich, Clay F., Marshall, Bess A., Hershey, Tamara, Umezawa, Akihiro, Greer, Peter A., Urano, Fumihiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267371/
https://ncbi.nlm.nih.gov/pubmed/25422446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421055111
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