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CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow

Leukocyte residence in lymphoid organs is controlled by a balance between retention and egress-promoting chemoattractants sensed by pertussis toxin (PTX)–sensitive Gαi protein–coupled receptors (GPCRs). Here, we use two-photon intravital microscopy to show that immature B cell retention within bone...

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Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Beck, Thomas C., Gomes, Ana Cordeiro, Cyster, Jason G., Pereira, João P.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267240/
https://ncbi.nlm.nih.gov/pubmed/25403444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140457
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