DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear deformation abnormalities that do not impair...

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Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Zhang, Qian, Dove, Christopher G., Hor, Jyh Liang, Murdock, Heardley M., Strauss-Albee, Dara M., Garcia, Jordan A., Mandl, Judith N., Grodick, Rachael A., Jing, Huie, Chandler-Brown, Devon B., Lenardo, Timothy E., Crawford, Greg, Matthews, Helen F., Freeman, Alexandra F., Cornall, Richard J., Germain, Ronald N., Mueller, Scott N., Su, Helen C.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267229/
https://ncbi.nlm.nih.gov/pubmed/25422492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141307
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