The proline-rich region of 18.5 kDa myelin basic protein binds to the SH3-domain of Fyn tyrosine kinase with the aid of an upstream segment to form a dynamic complex in vitro

The intrinsically disordered 18.5 kDa classic isoform of MBP (myelin basic protein) interacts with Fyn kinase during oligodendrocyte development and myelination. It does so primarily via a central proline-rich SH3 (Src homology 3) ligand (T92–R104, murine 18.5 kDa MBP sequence numbering) that is par...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: De Avila, Miguel, Vassall, Kenrick A., Smith, Graham S. T., Bamm, Vladimir V., Harauz, George
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266924/
https://ncbi.nlm.nih.gov/pubmed/25343306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20140149
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