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Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes

Our objective was to determine if the resistance mechanism to moxidectin (MOX) is similar of that to ivermectin (IVM) and involves P-glycoproteins (PGPs). Several Caenorhabditis elegans strains were used: an IVM and MOX sensitive strain, 13 PGP deletion strains and the IVM-R strain which shows synth...

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Podrobná bibliografie
Vydáno v:Int J Parasitol Drugs Drug Resist
Hlavní autoři: Bygarski, Elizabeth E., Prichard, Roger K., Ardelli, Bernadette F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266813/
https://ncbi.nlm.nih.gov/pubmed/25516824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2014.06.002
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