Antigenic Differences between AS03 Adjuvanted Influenza A (H1N1) Pandemic Vaccines: Implications for Pandemrix-Associated Narcolepsy Risk

BACKGROUND: Narcolepsy results from immune-mediated destruction of hypocretin secreting neurons in hypothalamus, however the triggers and disease mechanisms are poorly understood. Vaccine-attributable risk of narcolepsy reported so far with the AS03 adjuvanted H1N1 vaccination Pandemrix has been man...

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Bibliographic Details
Published in:PLoS One
Main Authors: Vaarala, Outi, Vuorela, Arja, Partinen, Markku, Baumann, Marc, Freitag, Tobias L., Meri, Seppo, Saavalainen, Päivi, Jauhiainen, Matti, Soliymani, Rabah, Kirjavainen, Turkka, Olsen, Päivi, Saarenpää-Heikkilä, Outi, Rouvinen, Juha, Roivainen, Merja, Nohynek, Hanna, Jokinen, Jukka, Julkunen, Ilkka, Kilpi, Terhi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266499/
https://ncbi.nlm.nih.gov/pubmed/25501681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114361
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