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Chemoenzymatic Synthesis of Spinosyn A

Following the biosynthesis of polyketide backbones by polyketide synthases (PKSs), post-PKS modifications result in a significantly elevated level of structural complexity that renders the chemical synthesis of these natural products challenging. We report herein a total synthesis of the widely used...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Kim, Hak Joong, Choi, Sei-hyun, Jeon, Byung-sun, Kim, Namho, Pongdee, Rongson, Wu, Qingquan, Liu, Hung-wen
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266379/
https://ncbi.nlm.nih.gov/pubmed/25287333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201407806
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