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Detection of DNA Synthesis in Intact Organisms with Positron-Emitting [Methyl-(11)C]Thymidine

(11)CO(2) produced in the Brookhaven 152-cm cyclotron was converted to formaldehyde, which in turn was used for the enzymatic conversion of deoxyuridine-5′-phosphate to [(11)C]thymidylate. Enzymatic treatment of the nucleotide with alkaline phosphatase gave [(11)C]thymidine. The preparation of [(11)...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Christman, David, Crawford, Elizabeth J., Friedkin, Morris, Wolf, Alfred P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1972
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC426610/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4554538/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.69.4.988
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